Ua paʻi nā mea kūʻai aku o ke Kula o Life Science, Sichuan University i nā pepa helu kiʻekiʻe me ka hoʻohana ʻana i nā huahana Foregene, me ka hopena o 17.848.

I kēia mau lā, ua paʻi ka hui Song Xu mai ke Kula ʻo Life Science o ke Kulanui ʻo Sichuan i kahi pepa uhi i kapa ʻia.ʻO nā kumu coagulation VII, IX a me X he mau protein antibacterial e kūʻē i ka lāʻau-kūʻē i ka Gram-negative Bacteria i ka Cell Research.

ʻO ka Cell Research kahi puke pai honua i paʻi pū ʻia e ka Chinese Academy of Science a me ka British Nature Publishing Group, he mea mana loa i ka honua kula.

I ka manawa i paʻi ʻia ai kēia ʻatikala, ua hoʻomaka koke ia i kahi manaʻo i ke kula.I kēia manawa, ua loaʻa nā hopena noiʻi e ka nui o nā media e like me Xinhua News Agency, World Wide Web, Phoenix Net, Southern Metropolis Daily,Biological Valley, British Daily Mail, American Daily Science, EurekAlert1!, Springer Nature, Phys.org, etc., BioMedCentral a me nā puke pai kaulana ʻē aʻe he nui nā hōʻike, a ke ulu mau nei ka nānā honua i kēia hopena noiʻi.

Ua hōʻike ka ʻatikala ʻo nā mea coagulation ʻekolu VII, IX a me X e pāʻani nei i ka hoʻomaka ʻana o ka coagulation cascade he ʻano hou o ka endogenous host antibacterial protein, ʻo ia hoʻi, nā mea coagulation VII, IX a me X he mau kuleana koʻikoʻi i ke kaʻina coagulation.Hiki paha iā ia ke hakakā me ka maʻi bacteria Gram-negative, me ka "super bacteria" kūpaʻa loa e like me Pseudomonas aeruginosa a me Acinetobacter baumannii.

Ua ʻōlelo ʻo Song Xu, ka mea kākau o kēia ʻatikala: "I ka wā ma mua, ua manaʻo nui ʻia e hiki i nā kumu coagulation ke hoʻoulu i ka thrombosis, akā ua hōʻike kēia haʻawina i loaʻa i nā kumu coagulation ka hopena kūikawā o ka sterilization.ʻO kēia ka ʻike mua ma ka home a ma waho.”

Noiʻi Ka hope

E like me kā mākou e ʻike ai, ua lilo ke kū'ē bacteria i pilikia olakino koʻikoʻi o ka honua.Hōʻike ka ʻikepili pili kokoke i ka 1 miliona mau kānaka e make i nā maʻi bacteria kūʻē i ka lāʻau lapaʻau i kēlā me kēia makahiki.Inā ʻaʻohe hopena maikaʻi aʻe, ʻo ka nui o nā make i kēlā me kēia makahiki mai 2050 he 10 miliona.

ʻO ka hoʻomāinoino ʻana i nā lāʻau lapaʻau, i hui pū ʻia me ka hiki ke hoʻololi maikaʻi ʻia o ka maʻi bacteria, ua hana i kekahi mau bacteria pathogenic i hiki ke pepehi ʻia e nā lāʻau antibacterial e lilo i lāʻau kūʻē i ka lāʻau, a lilo i "super bacteria".

Eia kekahi, i ka hoʻohālikelike ʻia me Gram-positive bacteria (Gram+), ʻoi aku ka paʻakikī o ka pepehi ʻana i nā bacteria maikaʻi ʻole (Gram-) ma muli o ke alo o ka membrane o waho (ʻo ka mea nui ʻo LPS, alias endotoxin, lipopolysaccharide).ʻO ka membrane o waho he envelop i haku ʻia me ka membrane cell i loko, ka paia ʻili lahilahi a me ka membrane cell waho.

Ka moʻolelo noiʻi

Ua aʻo ka hui o Song Xu i ka hopena o nā kumu coagulation i ka mālama ʻana i nā maʻi maʻi ʻino, akā i ka makahiki 2009, ua ʻike ʻole ʻia e hiki i nā kumu coagulation ke pepehi i ka bacteria.I mea e wehewehe ai i ka hana bactericidal o nā kumu coagulation, he 10 makahiki ka papahana mai ka hoʻomaka ʻana o ka noiʻi a hiki i ka paʻi ʻana o ka pepa.

Loaʻa wale ʻia

I ka makahiki 2009, ua ʻike ʻole ka poʻe noiʻi e hiki i ka coagulation factor VII ke hakakā me Escherichia coli ma waena o nā kumu coagulation he ʻumikūmālua.

Aia ka Escherichia coli i ka hua bacteria Gram-negative i loko o ka bacteria.He paʻakikī kēia ʻano bacteria, no ka mea, ʻo ko lākou mau keena he membrane cell i loko, he paia ʻili lahilahi a me kahi membrane cell waho.Hiki i ka envelop ke mālama i nā lāʻau i waho a pale i ka bacteria mai ka "komo."

Hoʻopuka manaʻo

ʻO nā kumu coagulation kahi pūʻulu o nā protein i loko o ke koko e pili ana i ka hoʻopili koko.Ke hoʻoheheʻe ʻia ke kino o ke kanaka, hoʻāla ʻia nā ʻano coagulation like ʻole e hana i nā filament fibrin, kahi e hoʻopaʻa ai i ka ʻeha me nā platelets.Inā nele kekahi a i ʻole kekahi mau kumu coagulation, hiki mai nā pilikia coagulation.

Ua ʻike nā kānaka ʻepekema ʻo ka poʻe maʻi me ka coagulopathy e maʻa pinepine i nā maʻi bacterial e like me sepsis a me ka maʻi pneumonia.ʻO kēia pili i alakaʻi iā lākou e noʻonoʻo ʻaʻole hiki i nā mea coagulation ke pāʻani i kahi hana koʻikoʻi i ke kaʻina coagulation, akā loaʻa pū kekahi hopena anti-infection.

Haʻawina hohonu

I mea e noiʻi ai inā hiki i nā kumu coagulation ke hana i kahi ākea ākea o ka bacteria Gram-negative, ua hoʻomaka ka poʻe noiʻi e aʻo hohonu i kāna hana antibacterial.Ua ʻike lākou i ka helu coagulation VII a me nā kumu like IX a me ka helu X, hiki i kēia mau protein ʻekolu ke uha i ka envelop paʻa o ka hua bacteria gram-negative.

Nui nā mea antibacterial i loaʻa i ka cell metabolism a i ʻole nā ​​membrane cell, akā he ʻano hana like ʻole kēia mau mea coagulation ʻekolu.Hiki iā lākou ke hydrolyze LPS, ka mea nui o ka membrane waho bacteria.ʻO ka lilo ʻana o LPS he mea paʻakikī ke ola ʻana o nā bacteria Gram-negative.

E hele hou aku

Ua ʻimi hou ka hui noiʻi i ka mīkini a ʻike ʻia kēlāke hana nei ka protein coagulation factor ma luna o ka bacteria ma o kāna māhele kaulahao māmā, aʻo ka mea kaulahao kaumaha ʻaʻohe hopena antibacterial.

I loko o ka moʻomeheu moʻomeheu Laboratory, ua ʻike maopopo nā mea noiʻi ma hope o ka hoʻohui ʻana i ke kumu coagulation a i ʻole kāna mau kaulahao māmā, ua hōʻino mua ʻia ka envelop cell bacterial, a laila i loko o 4 mau hola, ua aneane pau loa ka cell bacteria.

E hoʻohui i ka ʻāpana kaulahao māmā kumu VII i ka moʻomeheu Escherichia coli,

Ua pōʻino nā ʻāpana membrane waho bacteria, luku ʻia nā cell

ʻAʻole ʻo Escherichia coli wale nō, akā ʻo kekahi mau hua bacteria Gram-negative ʻē aʻe i hoʻāʻo ʻia i "hoʻopiʻi ʻia", me ka Pseudomonas aeruginosa a me Acinetobacter baumannii.Ua helu ʻia kēia mau bacteria ʻelua e ka World Health Organization (WHO) ma ke ʻano he 12 mau bacteria weliweli loa i ke olakino kanaka ma muli o ko lākou kūʻē ʻana i ka lāʻau.

Hōʻoia hoʻokolohua

Ua hōʻoia hou nā hoʻokolohua holoholona ma hope i ka maikaʻi o nā kumu clotting e kūʻē i ka super bacteria.

Hoʻopili nā mea noiʻi i nā ʻiole me ka nui o ka Pseudomonas aeruginosa a i ʻole Acinetobacter baumannii.Ma hope o ka hoʻopaʻa ʻana i ke kaulahao māmā kumu VII, ua ola nā ʻiole;ʻoiai ʻo nā ʻiole i loko o ka hui hoʻomalu i hoʻopaʻa ʻia me ka paʻakai maʻamau he 24 Ua make nā mea āpau i ka maʻi ma hope o nā hola.

Ma hope o ka maʻi me ka super bacteria, hoʻokomo i ke kaulahao māmā factor VII

Hiki ke pāʻani i kahi hana pale a hoʻomaikaʻi nui i ke ola o nā ʻiole

Mea nui

I kēia manawa, ʻaʻohe mea antibacterial i ʻike maikaʻi ʻia ma ka hydrolyzing LPS.

ʻO ka wehewehe ʻana i ka mīkini antibacterial e pili ana i ka LPS hydrolysis a me nā ʻano antibacterial o nā kumu coagulation, i hui pū ʻia me ka hiki ke hana i kēia mau kumu coagulation ma kahi nui ma ke kumu kūʻai haʻahaʻa, hiki ke hāʻawi i kahi hoʻolālā hou e kūʻai aku ai i ka lāʻau kūʻē i ka lāʻau Gram-negative bacteria.

Eia kekahi, loaʻa i kēia hana nā manaʻo noiʻi ākea i ka hana lapaʻau.I kēia manawa, ʻaʻohe lāʻau antibacterial i ʻike ʻia i ka hopena ma ka hydrolyzing LPS.ʻO ka hoʻohui ʻana i nā waiwai antibacterial o FVII, FIX, a me FX e kūʻē i ka LPS a me ka hana haʻahaʻa haʻahaʻa haʻahaʻa, manaʻo ʻia e hoʻomohala i nā lāʻau hou e kūʻē i nā maʻi "super bacteria".

Hoʻonui kumuhana

ʻOiai ʻoi aku ka kamaʻāina o ka poʻe i ka inoa "super bacteria", ʻo kā lākou huaʻōlelo pololei he "multi-drug resistant bacteria", e pili ana i kahi ʻano bacteria e kū kūʻē i nā lāʻau antibiotic.

E like me ka mea i ʻōlelo ʻia ma mua, ʻo ka piʻi ʻana o ke kūʻē ʻana o ka bacteria ma muli o ka hoʻohana kūpono ʻole a i ʻole ka hōʻino ʻana i nā antibiotics.No ka laʻana, ka hoʻohana pinepine ʻana i nā lāʻau antibiotic ākea ākea i ka mālama ʻana i nā maʻi maʻi hanu.

ʻO ka maʻi maʻi hanu he maʻi i kamaʻāina mākou a pau.Wahi a nā ʻikepili, ua maʻi ʻia kēlā me kēia keiki ma kahi o 6 a 9 mau manawa o ka makahiki, a ʻo nā ʻōpio a me nā pākeke ka maʻi ma kahi o 2 a 4 mau manawa i ka makahiki.

No ka mea, ʻo nā maʻi maʻi hanu he mau keʻena ulia pōpilikia, ʻo ka paʻakikī nui loa no nā kauka pilikia i ka wā e kū ana i nā maʻi ʻaʻole hiki iā lākou ke loaʻa ka ʻike pathogenic i ka manawa pōkole.No laila, ʻo ka lag o nā hoʻokolohua pathogenic e pono ai i nā kauka ke hoʻohana i nā lāʻau antibiotic ākea ākea (hiki ke kūpono).No nā ʻano bacteria he nui).

ʻO kēia ke ʻano o ka lāʻau lapaʻau "hoʻolaha i kahi ʻupena nui" i alakaʻi i kahi pilikia koʻikoʻi o ka kūʻē ʻana i ka lāʻau bacterial.No ka mea, i ka wā e pepehi mau ʻia ai ka hapa nui o nā maʻi paʻakikī, e hoʻonui ʻia nā ʻano lāʻau kūʻē i ka lāʻau e pani ai i nā ʻano paʻakikī, a e hoʻomau ka piʻi ʻana o ke kūʻē ʻana o ka bacteria i ka lāʻau.

No laila, inā hiki ke loaʻa kahi hōʻike ʻike pathogen pololei i loko o kahi manawa pōkole e alakaʻi i nā kauka i ke kuhikuhi ʻana i ka lāʻau kūpono, hiki ke hoʻemi nui ʻia ka hoʻohana ʻana i nā lāʻau lapaʻau ākea ākea, a laila e hoʻēmi i ka pilikia o ka pale ʻana i ka bacteria.

I mua o kēia pilikia kūpono, ua hoʻomaka ka hui noiʻi ʻepekema ʻo Fuji e hoʻomohala i kahi pahu ʻike pathogen hanu 15 mau mea.

Hoʻohana kēia pahu i ka hui pū ʻana o Direct PCR a me ka ʻenehana PCR multiplex, hiki ke ʻike iā Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Haemophilus influenzae a me nā 15 ʻē aʻe maʻamau o ka hanu haʻahaʻa i loko o ka sputum ma kahi o 1 hola.Hiki ke hoʻokaʻawale maikaʻi ka bacteria pathogenic ma waena o ka bacteria colonizing (maʻamau bacteria) a me ka bacteria pathogenic.Manaʻo wau e manaʻo ʻia he mea hana pono ia e kōkua i nā kauka i ka hoʻohana pono ʻana i ka lāʻau lapaʻau.

I ke alo o ka "super bacteria", ka ʻenemi lehulehu o ka poʻe holoʻokoʻa, ʻaʻole i lawe maʻalahi ke kanaka.Ma ke kahua o ka ʻepekema ola, nui nā mea noiʻi e like me ka hui ʻo Song Xu e hoʻoikaika ikaika nei e ʻimi a hana mālie ma ke ala e ʻimi ai i nā hopena "super bacteria".

Ma ʻaneʻi, ma ka ʻaoʻao o nā hoa olaola a me nā mea pōmaikaʻi, makemake ʻo Fortune Biotech e hōʻike i kona mahalo kiʻekiʻe i nā ʻepekema āpau i hāʻawi i kā lākou hoʻoikaika a me ka hou i kēia, a pule pū hoʻi i hiki i nā kānaka ke lanakila i ka "super bacteria" i ka wā hiki loa a loaʻa ke ola palekana a olakino.puni.